Related Experiment Video
Updated: Jan 16, 2026
08:18
Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
623
Phosphaturic Mesenchymal Tumor Originating in the Orbit
Jordan N Cornwell1, Matthew J Lee1, Katherine M Lucarelli1
1Division of Orbital and Ophthalmic Plastic Surgery, Doheny and Stein Eye Institutes, University of California, Los Angeles.
Ophthalmic Plastic and Reconstructive Surgery
|September 29, 2025
Summary
A rare orbital phosphaturic mesenchymal tumor (PMT) caused bone pain and fractures. Treatment resolved symptoms, highlighting PMTs as a diagnosis for bone pain with eye issues.
Area of Science:
- Oncology
- Ophthalmology
- Endocrinology
Background:
- Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms linked to tumor-induced osteomalacia.
- Orbital PMTs are exceptionally rare, presenting diagnostic challenges.
Purpose of the Study:
- To report a unique case of a primary orbital PMT.
- To discuss the diagnostic and therapeutic implications of this rare tumor.
Main Methods:
- Case presentation of a 53-year-old female with bone pain and an incidental orbital mass.
- Diagnostic workup included imaging (MRI, PET), laboratory tests (PTH, IgG4), and histology (FGFR23 positivity).
- Treatment involved surgery and external beam radiation therapy.
Main Results:
- The patient presented with diffuse bone pain and fractures, along with an orbital mass.
- Histology confirmed PMT with FGFR23 positivity.
- Post-treatment, bone pain and double vision resolved, and tumor size significantly reduced.
Conclusions:
- Orbital PMTs, though rare, should be considered in patients with unexplained bone pain and ocular symptoms.
- Multidisciplinary management involving ophthalmology, endocrinology, and radiation oncology is crucial.
- PMTs have a favorable prognosis with appropriate treatment.
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