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Updated: Jan 16, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Silymarin-alpha lipoic acid and metabolic dysfunction-associated steatotic liver disease: Insights and methodological
Froylan David Martínez-Sánchez1, Sophia Eugenia Martínez-Vázquez1, Ricardo Gutiérrez-Monterrubio1
1Department of Gastroenterology and Hepatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan 14080, CDMX, Mexico.
Abstract:
The trial by Cano Contreras et al examined a proprietary formulation containing Silybum marianum and alpha-lipoic acid (SM-ALA), combined with a Mediterranean diet, in patients with metabolic dysfunction-associated steatotic liver disease. While some metabolic benefits were observed, limitations such as the absence of an SM-ALA-only group, the lack of histological data, and a small sample size reduce the validity of the findings. Future research should follow clinical trial standards for pharmacological studies, including phase 1/2 testing, validated outcomes, and transparency.
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