Gut-skin axis: Emerging insights for gastroenterologists-a narrative review

Area of Science:

• Gastroenterology and Dermatology
• Microbiome Research
• Immunology

Background:

• The gut-skin axis (GSA) describes the bidirectional communication between the gastrointestinal system and skin.
• Gut dysbiosis and increased intestinal permeability are linked to skin diseases like acne, psoriasis, and atopic dermatitis.
• Cutaneous manifestations are common in GI diseases, providing diagnostic and therapeutic clues.

Purpose of the Study:

• To review the mechanisms of the GSA, emphasizing the role of the gut microbiome and its metabolites.
• To highlight the clinical significance of microbiome-targeted therapies for GI and skin disorders.
• To provide gastroenterologists with insights for managing skin conditions related to GI health.

Main Methods:

• Literature review focusing on the gut-skin axis mechanisms.
• Analysis of the role of gut microbiota and metabolites in inflammation and immunity.
• Examination of GI conditions and their impact on skin health.

Main Results:

• The gut microbiome and its metabolites are key regulators of inflammation and immunity within the GSA.
• Microbiome-targeted therapies (probiotics, prebiotics, diet) show promise for treating both GI and skin conditions.
• GI diseases like IBD and celiac disease significantly influence skin health.

Conclusions:

• The GSA is a critical area for understanding and managing complex diseases.
• Interdisciplinary collaboration between gastroenterology and dermatology is essential for optimizing patient care.
• Further research is needed to fully elucidate GSA mechanisms and therapeutic potential.