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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
Published on: January 4, 2018
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K2S2O8/DMSO-Mediated Organic Transformations: A Comprehensive Report.
1Department of Chemistry, University of Lucknow, Lucknow, UP, 226007, India.
Chemistry, an Asian Journal
|September 30, 2025
Summary
The potassium persulfate (K2S2O8) and dimethyl sulfoxide (DMSO) catalytic system offers a green, efficient, and versatile approach for complex organic transformations. This review highlights its applications in C-C and C-X bond formations and other functionalizations.
Area of Science:
- Organic Chemistry
- Green Chemistry
- Catalysis
Background:
- Sustainable and efficient C-C and C-X bond formations are crucial in organic synthesis.
- Traditional methods often involve harsh conditions or toxic reagents.
- There is a growing need for environmentally benign and cost-effective synthetic strategies.
Purpose of the Study:
- To provide a comprehensive overview of the K2S2O8/DMSO catalytic system.
- To discuss its mechanistic insights, synthetic applications, and future potential.
- To establish K2S2O8/DMSO as a key resource for sustainable organic synthesis.
Main Methods:
- Review of recent literature on K2S2O8/DMSO catalyzed reactions.
- Analysis of mechanistic pathways involved in various transformations.
- Compilation of diverse synthetic applications, including cyclization and coupling reactions.
Main Results:
- K2S2O8/DMSO system demonstrates high efficiency, affordability, and mild reaction conditions.
- Effective in a wide range of transformations: cyclization, C-C/C-X coupling, oxygenation, and deoxygenation.
- Established as a versatile and environmentally friendly catalytic system.
Conclusions:
- The K2S2O8/DMSO system is a powerful tool for green organic synthesis.
- It offers a sustainable alternative for various complex chemical transformations.
- Further research can expand its utility in developing novel synthetic methodologies.
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