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Updated: Jul 13, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
Polyacrylic Acid-Based Chlorella Loading Hydrogel Featuring Antibacterial and Microenvironment Remodeling Properties
Siyuan Yuan1, Yongjie Zhang1, Xiaomei Dai1
1Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.
None:
Polyacrylic acid (PAA)-based hydrogels have been widely used in commercial wound dressings. However, they may trigger a series of adverse reactions within biological organisms due to PAA's nonbiodegradable nature and the difficulty of metabolism in physiological environments. To overcome this issue, a degradable PAA derivative (PLC) containing acrylic acid, α-lipoic acid (LA), and 2-(N-3-sulfopropyl-N,N-dimethylammonium)ethyl methacrylate was synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization. Then, a multifunctional PLC-based hydrogel (CAPLCT@Chlorella) was developed through a facile mixture of PLC, tannic acid (TA), l-arginine-coupled chitosan (CA), and Chlorella. Chlorella in the hydrogel could constantly generate oxygen (O2) through photosynthesis, relieving hypoxia. CA in the hydrogel endows CAPLCT@Chlorella the release of nitric oxide (NO), which could promote angiogenesis. The hydrogel not only exhibits excellent antibacterial and antibiofilm activities but can also relieve oxidative stress and modulate the inflammatory microenvironment. CAPLCT@Chlorella offers a promising therapeutic option for bacteria-infected wound healing.
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