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The role of non-coding RNAs in pleural mesothelioma

Giulia Tonnini1, Giulia Di Mauro2, Maria Letizia Tramarin1

  • 1Department of Medical Sciences, School of Medicine, University of Ferrara, Ferrara, Italy.

Translational Oncology
|September 30, 2025
PubMed
Abstract

Insights

Non-coding RNAs (ncRNAs) are crucial in pleural mesothelioma (PM) development. This review synthesizes ncRNA roles in PM, exploring their potential for diagnosis, prognosis, and targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pleural mesothelioma (PM) is a rare, aggressive cancer linked to asbestos exposure.
  • Late diagnosis and limited treatment options highlight the need for novel therapeutic strategies.

Purpose of the Study:

  • To review the current understanding of non-coding RNA (ncRNA) dysregulation in PM.
  • To explore the diagnostic, prognostic, and therapeutic potential of ncRNAs in PM.

Main Methods:

  • Summarized studies on ncRNA expression and function in PM tumors and biofluids.
  • Focused on ncRNA regulation of proliferation, apoptosis, and migration.
  • Examined competing endogenous RNA (ceRNA) networks in PM gene regulation.

Main Results:

  • ncRNAs, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are significantly dysregulated in PM.
  • ncRNAs influence key cellular processes such as proliferation, apoptosis, and cell migration in PM.
  • ceRNA networks play a critical role in modulating gene expression within the PM tumor microenvironment.

Conclusions:

  • This review integrates diverse ncRNA classes and their interactions, emphasizing the role of ceRNA networks in PM.
  • ncRNAs offer promising avenues for developing novel diagnostic biomarkers and therapeutic targets for PM.
  • Understanding ncRNA mechanisms provides a framework for advancing PM diagnosis, prognosis, and targeted treatment strategies.
Keywords:
Epigenetic modificationsNon-coding RNAsPMcircRNAslncRNAsmiRNAs

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