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Updated: Jan 16, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Natural-product-inspired potent anticancer congeners: chronological advancements, structure-activity relationship
Abdul Rahaman T A1, Nandini1, Tanmoy Tantra1
1Laboratory of Bioactive Heterocycles and Catalysis (BHC lab), Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli (Transit Campus), Bijnor-Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow 226002, India.
Abstract:
Cancer is among the leading causes of mortality and morbidity globally. Natural products have played a significant role in bringing novel therapies to the clinic for the treatment of various types of cancer. However, several natural products have low potency, chemical instability, poor pharmacokinetics, and high toxicity. Therefore, a natural-product-inspired strategy has been utilized to overcome the limitations of natural products in cancer drug discovery. Herein, we present a critical review to describe how medicinal chemists designed anti-cancer agents via a natural-product-inspired strategy. We have also illustrated how this approach is used to overcome drug resistance in cancer. The natural product-inspired analogues/derivatives were classified into different categories. Our focus extends to reviewing the design strategies, in vitro/in vivo results, and structure-activity relationship (SAR) studies of natural-product-inspired molecules as anti-cancer agents. We expect that this review will inspire the development of more effective and diversified anti-cancer agents.
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