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Updated: Jan 16, 2026
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
Published on: November 22, 2021
A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve
Mingjie Zhou1, Biao Yan1,2, Fukui Yang3
1Department of Hand Surgery, Huashan Hospital, National Health Commission Key Laboratory of Limbs Reconstruction, Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, National Clinical Research Center for Aging and Medicine, Institute of Hand Surgery, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Fudan University, Shanghai, PR China.
Abstract:
Peripheral nerve transfer is an effective surgical method in restoring motor functions of upper limb after peripheral nerve injuries. However, the outcome of individual function recovery is less predictable. It is crucial to access the long-term evaluation of function improvement. Here, we developed a fully implantable multisite optogenetic stimulation system, which is tailored for wireless, reprogrammable and long-term function evaluation of peripheral nerve plexus with sub nerve resolution. In Thy1-ChR2-EYFP mice, our system induced distinct compound muscle action potentials and forelimb movements when illuminating different nerve fascicles. Furthermore, we applied the system on a nerve transfer mice model after traumatic brain injury and discovered innervation pattern of the transferred and adjacent nerves to multiple muscles consecutively within 12 weeks after surgery. Our system enabled refined evaluation of electrophysiological and motor functions of peripheral nerve plexus, shining light upon personalized diagnosis and treatment after nerve injuries or surgeries.
