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A novel mouse model simulating C5 palsy after cervical surgery.

Chenpei Xu1,2,3,4,5, Xianghe Wang6,7, Mingjie Zhou1,2,3,4,5

  • 1Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Animal Models and Experimental Medicine
|April 2, 2026
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Summary

Researchers developed a new mouse model for C5 palsy (C5P) after cervical surgery. This reproducible model aids in studying permanent C5P and testing new interventions for better patient outcomes.

Keywords:
C5 palsycervical surgerycomplicationmouse modelnerve root injury

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Area of Science:

  • Neurosurgery
  • Animal Modeling
  • Nerve Injury Research

Background:

  • C5 palsy (C5P) incidence post-cervical surgery is high (>5%) with unclear pathogenesis.
  • Many patients lack satisfactory functional recovery, impacting quality of life.
  • A suitable animal model for permanent C5P research is currently unavailable.

Purpose of the Study:

  • To establish a novel, reproducible mouse model for permanent C5 palsy (C5P).
  • To facilitate research into the pathogenesis and treatment of C5P.
  • To enable exploration of new therapeutic interventions for C5P.

Main Methods:

  • A posterior intradural approach was used to selectively transect the C5 ventral root in mice.
  • Anatomical validation ensured precise C5 ventral root exposure while preserving the dorsal root.
  • Multimodal validation included behavioral, electrophysiological, and histological assessments.

Main Results:

  • The posterior intradural approach proved safe and effective, with successful survival of all mice.
  • Selective C5 ventral root transection was achieved, preserving the dorsal root.
  • Behavioral, electrophysiological, and histological data confirmed motor deficits and nerve/muscle pathology.

Conclusions:

  • A simple, reproducible, and effective mouse model for permanent C5 palsy (C5P) has been developed.
  • This model is suitable for exploring potential new therapies for C5P.
  • The model supports research into nerve transfer surgery and advanced rehabilitation techniques.