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Related Experiment Video

Updated: Jan 16, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Introducing Enteric Glial Cells.

Giuseppe Esposito¹

¹Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, Rome, Italy. giuseppe.esposito@uniroma1.it.

Methods in Molecular Biology (Clifton, N.J.)

|October 1, 2025

Summary

This summary is machine-generated.

Enteric glial cells are crucial for gut health and the gut-brain axis, impacting inflammatory bowel and neurodegenerative diseases. Researching these cells offers new therapeutic strategies for gastrointestinal and neurological conditions.

Keywords:

Enteric Glia Gastroenterology Molecular biology Multidisciplinary techniques Neuroscience Pharmacology

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An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

Area of Science:

Neuroscience
Gastroenterology
Cell Biology

Background:

Enteric glial cells, known since the late 19th century, are increasingly recognized for their vital roles.
Their functions are critical in inflammatory bowel diseases and potential links to Parkinson's disease.
Understanding enteric glial cells is key to unraveling gut disorders and their impact on brain health.

Purpose of the Study:

To provide a comprehensive guide on identifying, visualizing, and isolating enteric glial cells.
To explore the behavior, activation states, and morphological diversity of these cells.
To investigate innovative approaches for studying enteric glia using advanced models and human samples.

Main Methods:

Enzymatic digestion for cell isolation.
Immunofluorescence and confocal microscopy for visualization.
Utilizing transgenic models and human biopsies for activity studies.

Main Results:

Detailed protocols for enteric glial cell manipulation and analysis.
Insights into glial cell responses to inflammation and microbiome interactions.
Exploration of glial cell roles in disease pathogenesis.

Conclusions:

Enteric glial cells are significant targets for novel therapies in gastrointestinal and neurological diseases.
Cell-based interventions, including transplantation, show therapeutic potential.
This research bridges gastrointestinal and neurological fields, highlighting gut-brain communication.