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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Selective serotonin reuptake inhibitors enhance cancer immunosurveillance by pleiotropic mechanisms
Karla Alvarez-Valadez1, Guido Kroemer1,2,3, Mojgan Djavaheri-Mergny1
1Team Metabolism, Cancer & Immunity, Centre de Recherche des Cordeliers, INSERM UMRS1138, Sorbonne Université, Université de Paris Cité, Institut Universitaire de France, Paris, France.
Abstract:
In a recent paper published in Cell, Li et al. suggest that selective serotonin reuptake inhibitors (SSRIs) antidepressants act on serotonin transporters on CD8+ T cells to enhance antitumor immunity. Beyond this mechanism, SSRIs can act on malignant cells, as well as on other immune cells, to improve cancer immunosurveillance.
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