Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review

Area of Science:

• Oncology
• Pharmacology
• Natural Products Chemistry

Background:

• Pancreatic cancer is a deadly disease with poor survival rates.
• Current treatments have limitations, necessitating novel therapeutic strategies.

Purpose of the Study:

• To review natural compounds as potential therapeutics for pancreatic cancer.
• To explore the mechanisms of action and clinical potential of these compounds.

Main Methods:

• Literature review of studies on natural compounds and pancreatic cancer.
• Analysis of preclinical and clinical data on polyphenols, saponins, and alkaloids.
• Examination of indirect effects on gut microbiota, metabolism, and endocrine system.

Main Results:

• Natural compounds exhibit anti-pancreatic cancer activities, including inhibiting cell growth, inducing apoptosis, and preventing angiogenesis.
• These compounds influence pancreatic cancer indirectly via gut microbiota and metabolic pathways.
• Chinese herbal medicines show clinical promise.

Conclusions:

• Natural compounds offer a promising avenue for pancreatic cancer therapy.
• Challenges include target identification and bioavailability, requiring further investigation.
• Interdisciplinary collaboration and advanced technologies are crucial for future development.