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Performance qualification of impedance flow cytometry as a rapid in-process control proxy for Colony-forming units in

Peter Lüttge Jordal1, Marcos González Díaz1, Frederik Aalund1

  • 1SBT Instruments A/S, Symfonivej 37, DK-2730 Herlev, Denmark.

Journal of Microbiological Methods
|October 1, 2025
PubMed
Abstract

Keywords:
Colony-forming unitsFermentationImpedance flow cytometryPerformance qualificationReal-timeValidation

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Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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