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Updated: Jan 16, 2026

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
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Novel therapies in SSc.

Janet Pope1

  • 1Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Division of Rheumatology, Department of Medicine, St. Joseph's Health Care, 268 Grosvenor St., London, ON, N6A 4V2, Canada.

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Summary

Systemic sclerosis (SSc) treatments need novel therapies to improve patient quality of life and survival. This review focuses on immune modification for skin and lung disease, highlighting transformative treatments for SSc.

Keywords:
BiTECAR-TClinical trialsDiffuseILDLimitedNovel therapiesPAHProgressive pulmonary fibrosisPulmonary arterial hypertensionSclerodermaSystemic sclerosis

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Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis and vasculopathy.
  • Current evidence-based guidelines exist but lack a definitive cure, significantly impacting patient quality of life and survival.
  • Novel therapeutic strategies are crucial for preventing organ damage and improving outcomes in SSc.

Purpose of the Study:

  • To review how novel therapies can enhance the standard of care for Systemic sclerosis.
  • To focus on immune modification strategies for skin involvement, interstitial lung disease, and pulmonary hypertension in SSc.
  • To highlight potentially transformative treatments and their future role in SSc management.

Main Methods:

  • Literature review of recent and ongoing clinical trials.
  • Focus on immune-modulating therapies for specific SSc manifestations.
  • Exclusion of studies on Raynaud's phenomenon and other organ systems due to limited ongoing research.

Main Results:

  • Identification of novel therapeutic targets and agents for SSc.
  • Evaluation of the potential impact of these therapies on skin fibrosis, interstitial lung disease, and pulmonary hypertension.
  • Discussion of how these treatments may integrate into future SSc care standards.

Conclusions:

  • Novel therapies hold significant promise for improving the management of Systemic sclerosis.
  • Immune modification strategies are key areas for developing transformative treatments in SSc.
  • Further research and clinical trials are essential to establish new standards of care for SSc patients.