Related Experiment Video
Updated: Jan 16, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Small Cell Lung Cancer: A Dramatic
Koichi Yano1, Takuto Ishida1, Kyoko Yokosuka1
1Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Japan.
Abstract:
Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for malignant tumors in patients with severe neurological conditions. We herein report a 66-year-old male who fell into a coma caused by anti-NMDAR encephalitis associated with small cell lung cancer (SCLC). Corticosteroid pulse therapy failed to improve his neurological condition, but a chemotherapy regimen containing atezolizumab led to rapid improvement in his condition. This case suggests that chemotherapy, including atezolizumab, may provide a rapid therapeutic benefit for anti-NMDAR encephalitis associated with SCLC.
More Related Videos
10:19High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...