Related Experiment Video
Updated: Jan 16, 2026
04:32
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
Published on: June 5, 2019
8.1K
Ampicillin-dependent IgG Antibody Mediated Thrombocytopenia Confirmed Using Flow Cytometry
Ayane Ikeda1, Tatsuya Konishi2, Masaki Maruta1
1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|October 1, 2025
Summary
Ampicillin (ABPC) rarely causes drug-induced immune thrombocytopenia (DITP). In this case, discontinuing ABPC led to prompt platelet recovery, confirmed by flow cytometry showing ABPC-dependent IgG binding.
Area of Science:
- Immunology
- Hematology
- Pharmacology
Background:
- Drug-induced immune thrombocytopenia (DITP) is a rare but serious adverse drug reaction.
- Ampicillin (ABPC) is an uncommon cause of DITP.
- Accurate diagnosis and prompt management are crucial for patient outcomes.
Purpose of the Study:
- To report a rare case of DITP caused by ampicillin (ABPC).
- To demonstrate the utility of flow cytometry in diagnosing ABPC-induced DITP.
- To emphasize the importance of early drug withdrawal in managing DITP.
Main Methods:
- Case report of an 87-year-old female patient with severe thrombocytopenia.
- Evaluation of treatment response to oral prednisolone and intravenous immunoglobulin.
- Application of flow cytometry to detect drug-dependent antibodies against platelets.
Main Results:
- The patient developed severe thrombocytopenia during ABPC treatment for periprosthetic infection.
- Platelet counts did not improve with standard DITP treatments but recovered rapidly after ABPC discontinuation.
- Flow cytometry confirmed the presence of ampicillin-dependent IgG binding to platelets.
Conclusions:
- This case highlights ampicillin as a potential cause of DITP.
- Flow cytometry provides a valuable diagnostic tool for identifying drug-dependent platelet antibodies.
- Early recognition and withdrawal of the causative agent are essential for managing DITP effectively.
