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Updated: Jan 16, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic
Xiwen Bai1,2, Zhihan Liu3, Xianbin Li1,2
1Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Abstract:
Hepatic fibrosis, a critical progression in liver disease, has been widely studied. While the activation of stellate cells and the accumulation of extracellular matrix components are recognized as key mechanisms, additional research is necessary to uncover further complexities. Recent investigations underscore the pivotal role of post-translational modifications (PTMs) in hepatic fibrosis. This study explores nine PTMs-methylation, acetylation, SUMOylation, Neddylation, phosphorylation, crotonylation, glycosylation, lactylation, and ubiquitination-each implicated in the pathogenesis of hepatic fibrosis. Furthermore, six classes of drugs-ACC inhibitors, ASK1 inhibitors, Akt activators, FXR agonists, PTP1B inhibitors, and HDAC inhibitors-are reviewed for their therapeutic potential in targeting PTMs to treat hepatic fibrosis.
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