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Related Experiment Video

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Automation of Mode Locking in a Nonlinear Polarization Rotation Fiber Laser through Output Polarization Measurements
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Phase-Sensitive Surface Plasmon Resonance Imaging with Polarization Modulation and Stokes Vector Measurement.

Baiqi Cui1, Xiaoyin Liu1, Jinbiao Ma1

  • 1Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

ACS Sensors
|October 2, 2025
PubMed
Summary
This summary is machine-generated.

A new Stokes vector-based polarization SPR imaging system offers enhanced sensitivity for biomolecular detection. This advanced phase-sensitive surface plasmon resonance (P-SPR) technique enables label-free quantification and multidimensional biosensing.

Keywords:
Stokes vector measurementmolecular interactionphase-sensitive SPRpolarization modulationsmall molecules

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Area of Science:

  • Biosensing and Nanophotonics
  • Surface Plasmon Resonance (SPR) Technology
  • Polarization Optics and Imaging

Background:

  • Conventional intensity-based SPR methods lack the sensitivity of phase-sensitive techniques.
  • Existing phase-sensitive SPR (P-SPR) implementations have limitations in optical complexity, phase resolution, and full polarization information access.
  • There is a need for advanced P-SPR systems offering improved sensitivity and comprehensive data acquisition.

Purpose of the Study:

  • To develop a compact and versatile Stokes vector-based polarization SPR imaging (Sp-SPRi) system.
  • To overcome the limitations of current P-SPR techniques by enabling simultaneous acquisition of phase and multiple polarization parameters.
  • To enhance molecular measurement capabilities and broaden the analytical scope of P-SPR.

Main Methods:

  • Implementation of a Stokes vector-based polarization modulation and analysis for SPR imaging.
  • Utilizing full Stokes vector analysis of imaging light to extract phase and polarization information.
  • Development of a compact optical configuration with microfluidic integration for high-throughput imaging.

Main Results:

  • Achieved a high phase sensitivity of 1.80 × 10-7 refractive index units (RIU).
  • Demonstrated successful kinetic, label-free detection and quantification of biomolecular interactions.
  • Validated performance through kinetic measurements of protein binding, small molecule interactions, and in situ glycoprotein analysis in single cells.

Conclusions:

  • The Sp-SPRi system provides a powerful platform for multidimensional biosensing with simplified optics and high-throughput capabilities.
  • This technique broadens the analytical scope of P-SPR, offering robust and accessible molecular measurement.
  • The Sp-SPRi system holds significant potential for applications in point-of-care diagnostics, early disease detection, and drug screening.