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Cognitive Function 1 Year After COVID Infection.

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One year after COVID-19 infection, cognitive function in adults aged 45 did not decline. This study tracked cognitive changes in individuals post-SARS-CoV-2 infection using objective assessments.

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Cognitive Science

Background:

  • Emerging evidence suggests a possible link between COVID-19 and cognitive impairment.
  • Prospective longitudinal research objectively assessing cognitive outcomes after SARS-CoV-2 infection is lacking.
  • This study addresses the need for objective cognitive assessments post-COVID-19.

Purpose of the Study:

  • To evaluate cognitive function changes following COVID-19.
  • To compare cognitive outcomes in individuals with and without COVID-19 infection.
  • To provide objective data on the long-term cognitive effects of SARS-CoV-2.

Main Methods:

  • A cohort study design was employed.
  • Cognitive function was objectively measured using the computerized Cognivue Clarity® device.
  • Participants underwent baseline and approximately 1-year follow-up cognitive assessments, categorized by COVID-19 status.

Main Results:

  • In the COVID-19 positive group, only memory scores showed a statistically significant change (+3.9, P = .03).
  • The COVID-19 negative group demonstrated improvements in overall cognitive score (+2, P = .03) and subdomains.
  • No significant differences in overall cognitive scores or subdomains were found between the COVID-19 positive and negative groups.

Conclusions:

  • One year post-COVID-19 infection, no cognitive decline was observed in the average 45-year-old population.
  • Objective cognitive assessments did not reveal significant long-term detriments in this cohort.
  • Findings suggest that COVID-19 infection may not lead to a measurable decrease in cognitive function one year later in this demographic.