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Treatment Approach to Chronic Rhinosinusitis Based on Endotype: Difference Between East and West
Junhai Chen1,2,3, Linlu Wang1,2,3, Xinyue Wang1,2,3
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Summary
Differences in chronic rhinosinusitis with nasal polyps (CRSwNP) management stem from geographic variations in inflammation. Western CRSwNP patients often have Type 2 (T2) inflammation, while Eastern patients predominantly show non-T2 inflammation, requiring distinct therapeutic approaches.
Area of Science:
- Otolaryngology
- Immunology
- Pharmacology
Background:
- Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits significant heterogeneity globally.
- Western CRSwNP populations are characterized by a high prevalence of Type 2 (T2) inflammation.
- Eastern CRSwNP populations predominantly present with non-T2 inflammatory endotypes.
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