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Published on: April 23, 2012
Type B Trichothecenes in Grain-Based Foods: Method Validation and Analysis of Convenience Survey Samples
Kai Zhang1, Brenna M Flannery2, Selena Jiang1
1U.S. Food and Drug Administration, Human Foods Program, Office of Laboratory Operations and Applied Science, Office of Chemistry and Toxicology, Division of Bioanalytical Chemistry, Bioanalytical Method Branch, 5001 Campus Drive, College Park, Maryland 20747, United States.
None:
The FDA monitors deoxynivalenol in the food supply, with an advisory level of 1,000 ng/g established for finished wheat products. To better understand the presence of deoxynivalenol and related type B trichothecenes─nivalenol, 3- and 15-acetyl-deoxynivalenol, and deoxynivalenol-3-glucoside─in food products available in the United States market, we developed and validated a liquid chromatography-tandem mass spectrometry method for their determination. Using this method, we analyzed a convenience sampling of 61 infant/toddler products and 35 grain-based food products. The overall detection rate for the five type B trichothecenes was 24% (23/96), with deoxynivalenol being the most frequently detected mycotoxin (15-312 ng/g) in 14 infant/toddler and 8 grain-based food products. Neither 3- nor 15-acetyl-deoxynivalenol was detected in any samples. Co-occurrence of deoxynivalenol-3-glucoside and deoxynivalenol was found in 8 of the 14 infant/toddler products with positive detects, with concentration ratios ranging from 0.1 to 0.7.
