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Optimization of pyrrole-2-carboxamide to develop a potent antituberculosis agent with improved physicochemical

Yanan Wu1, Hongyi Zhao1, Bin Wang2

  • 1State Key Laboratory of Respiratory Health and Multimorbidity, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China.

Bioorganic Chemistry
|October 2, 2025
PubMed

Keywords:
Antituberculosis activityDruggabilityMmpL3OptimizationPhysicochemical property

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