Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.1K
Muscles for Facial Expressions01:14

Muscles for Facial Expressions

4.7K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
4.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

228
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
228
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Applications of Pure Recombinant Human Platelet-Derived Growth Factor BB in Esthetic Medicine and Plastic Surgery.

Facial plastic surgery clinics of North America·2026
Same author

Periorbital Rejuvenation Using Fat Grafting to Five Key Anatomic Areas.

Plastic and reconstructive surgery·2026
Same author

Suzetrigine: What Should Plastic Surgeons Know?

Plastic and reconstructive surgery. Global open·2026
Same author

The Invisible Scar: Energy-Based Facial Tightening Through the Lens of the Deep-Layer Facelift Surgeon.

Aesthetic surgery journal·2026
Same author

Ushering in a New Social Media Era in Aesthetic Surgery: AI-Generated Transformation Videos and Their Ethical Implications.

Aesthetic surgery journal·2026
Same author

The Peptide Plastic Surgeon: A Review of Evidence on Regenerative Peptide Supplementation and Potential in Aesthetic Plastic Surgery.

Aesthetic surgery journal·2026

Related Experiment Video

Updated: Jan 16, 2026

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
04:36

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components

Published on: July 11, 2025

1.1K

Rethinking filler strategy for the aging face.

Aaron L Wiegmann1, Tara M Chadab1, Rod J Rohrich1

  • 1Dallas Plastic Surgery Institute (DPSI), Dallas, TX, USA.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|October 2, 2025
PubMed
Summary

Facial rejuvenation with fillers is optimized by understanding aging patterns and fat compartments. A top-down approach prioritizes high-impact areas for effective volume restoration and enhanced appearance.

Keywords:
Facial agingFacial fillersFacial rejuvenationFat compartmentsTop-down sequenceVolume loss

More Related Videos

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.5K
Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

14.6K

Related Experiment Videos

Last Updated: Jan 16, 2026

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
04:36

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components

Published on: July 11, 2025

1.1K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.5K
Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

14.6K

Area of Science:

  • Aesthetic medicine and dermatology
  • Facial anatomy and aging

Background:

  • Growing popularity of minimally invasive cosmetic procedures like filler injections.
  • Increasing patient awareness driven by social media regarding facial rejuvenation options.
  • Facial aging is characterized by volume loss, necessitating targeted restoration strategies.

Purpose of the Study:

  • To present a standardized, top-down methodology for facial rejuvenation using dermal fillers.
  • To provide an algorithm for prioritizing treatment areas based on perceptual impact and volume enhancement.
  • To leverage expert experience in fat and filler-based facial volumization.

Main Methods:

  • A conceptual framework based on 25 years of clinical expertise in facial volumization.
  • Description of a standardized top-down approach for filler application in facial rejuvenation.
  • Development of a treatment algorithm to guide prioritization of facial areas.

Main Results:

  • The top-down approach facilitates a systematic evaluation of rejuvenation effects.
  • Prioritization of high-impact facial areas ensures efficient and effective volume restoration.
  • Judicious product use is achieved through a stepwise treatment strategy.

Conclusions:

  • Understanding facial fat compartments and aging patterns is crucial for optimizing filler treatments.
  • A standardized top-down methodology and prioritization algorithm enhance facial rejuvenation outcomes.
  • This approach promotes effective volume restoration and improved aesthetic results.