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Adipose-Derived Stem Cell Therapy Attenuates HIF-1α/mTOR/REDD1 Signaling in Obese Hypertensive Rats

Renata Nakamichi1, Mario Luis Ribeiro Cesaretti1, Eric Rafael Andrade Silva1

  • 1Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 10 Andar, Vila Clementino, zip code: , 04039-032, Brazil.

Molecular Biomedicine
|October 2, 2025
PubMed
Abstract

No abstract available in PubMed .

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Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...