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Related Experiment Video

Updated: Jan 16, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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3D Printing Strategies for Bioengineering Human Cornea.

Yunong Yuan1,2, Khoon S Lim1,2, Gerard Sutton3,4

  • 1School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW, 2050, Australia.

Advanced Healthcare Materials
|October 3, 2025
PubMed
Summary
This summary is machine-generated.

3D bioprinting offers a promising solution to the global shortage of donor corneas for vision restoration. This review explores 3D printing strategies for creating artificial corneas with native-like optical and mechanical properties.

Keywords:
3D printingcorneamechanobiologyregenerative medicinetransparency

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Ophthalmology

Background:

  • Corneal diseases affect over 4.2 million people globally, with donor cornea scarcity limiting treatment options.
  • 3D printing (three-dimensional printing) technology presents a novel approach for corneal tissue engineering.
  • Existing reviews lack focus on cornea-specific requirements like transparency and mechanical strength.

Purpose of the Study:

  • To comprehensively review the current state of 3D printed cornea research.
  • To focus on replicating the biomechanical and optical properties of native human corneas.
  • To identify limitations and advancements in 3D bioprinting for corneal applications.

Main Methods:

  • Review of current literature on 3D bioprinting techniques and biomaterials for corneal tissue engineering.
  • Analysis of studies focusing on achieving specific corneal benchmarks: transparency, curvature, and mechanical robustness.
  • Evaluation of recent advancements in 3D bioprinting technologies for high-resolution, anisotropic, and multilayered construct fabrication.

Main Results:

  • 3D printing allows precise control over dimensionality, structural organization, and cell-matrix interactions in corneal constructs.
  • The selection of biomaterials and printing strategies is crucial for achieving desired corneal properties.
  • Recent advancements show potential for producing complex corneal structures with high fidelity.

Conclusions:

  • 3D bioprinting holds significant potential for addressing the global donor cornea shortage.
  • Scalable and clinically relevant solutions for corneal regeneration can be developed using 3D printing.
  • Further advancements in 3D printing technologies are central to realizing artificial corneas for transplantation.