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Updated: Jan 16, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Regenerative Evaluation of Collagen and an Advanced Platelet-rich Fibrin Membranes with Deproteinized Bovine Bone
Shweta Bhagat1, Priyanka Jaiswal2, Pavan Bajaj2
1Department of Periodontics and Implantology, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India, Phone: +91 8319131268,
Aim:
This study aimed to compare the effectiveness of bioresorbable collagen membrane and an advanced platelet-rich fibrin (A-PRF) membrane, both combined with deproteinized bovine bone matrix (DBBM) xenograft, in the treatment of human infrabony defects.
Materials And Methods:
Twenty-four patients (aged 28-54 years) with moderate to advanced periodontitis and infrabony defects were randomly assigned to two groups. Group A received open flap debridement with deproteinized DBBM xenograft and a bioresorbable collagen membrane, while group B received DBBM with A-PRF. Clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), gingival recession, radiographic bone fill, and oral hygiene status, were assessed at baseline and 6 months postoperatively.
Results:
At the 6-month follow-up after regenerative procedures, both treatment groups showed improvements in clinical parameters and radiographic bone gain. At 6 months, no significant difference in CAL gain was found between group A (3.5 ± 0.79 mm) and group B (3.66 ± 0.88 mm), with a mean difference of 0.16 ± 1.26 mm (p > 0.05). Additionally, the radiographic bone fill (%BF) in the DBBM + collagen membrane group was comparable to that in the DBBM + A-PRF membrane group, with no statistically significant difference.
Conclusions:
Within the limitations of this study, the combination of DBBM and a collagen membrane (group A) resulted in significantly more favorable clinical outcomes in terms of radiographic bone fill for infrabony defects as compared to group B.
Clinical Significance:
Both collagen and A-PRF membranes with DBBM significantly improved clinical and radiographic outcomes in treating infrabony defects. Advanced platelet-rich fibrin offers a promising autologous alternative to collagen, supporting effective periodontal regeneration without animal-derived barriers. How to cite this article: Bhagat S, Jaiswal P, Bajaj P, et al. Regenerative Evaluation of Collagen and an Advanced Platelet-rich Fibrin Membranes with Deproteinized Bovine Bone Matrix in Infrabony Defects: A Randomized Controlled Trial. J Contemp Dent Pract 2025;26(6):573-580.
