Related Experiment Video
Updated: Jan 16, 2026
Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
Published on: December 1, 2023
Phenomenological insights into the FLASH radiotherapy-induced abscopal effect
Paolo Castorina1,2,3, Gianluca Ferini4,5, Francesco Romano2
1Istituto Oncologico del Mediterraneo, Viagrande, Italy.
Background:
The abscopal effect suggests that the impact of radiotherapy extends beyond the direct tumor local regression, due to activation of the immune response. Its effectiveness may vary depending on whether high- or low-radiation doses are used. In FLASH therapy, the high-dose rate treatment induces systemic effects that may trigger an abscopal response.
Methods:
We discuss a phenomenological, computational model, based on available in vivo FLASH radiotherapy data, to quantitatively analyze the possible synergistic effects with the immune system to produce a systemic effect.
Results:
The method enables a quantitative assessment of the interaction between FLASH radiotherapy and the activated immune response, based on observations of metastatic shrinkage due to the FLASH treatment of the primary tumor.
More Related Videos
04:58Reduced Procedure Time and Variability with Active Esophageal Cooling During Radiofrequency Ablation for Atrial Fibrillation
Published on: August 25, 2022
05:43Author Spotlight: Improving Lesion Contiguity in Pulmonary Vein Isolation via Proactive Esophageal Cooling
Published on: April 19, 2024
