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Updated: Jul 10, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Brain activation generated by periodontal initial treatment.

Kosuke Muraoka¹, Masafumi Oda², Kenichi Yoshino³

¹Division of Clinical Education Development and Research, Faculty of Dentistry, Kyushu Dental University, Kitakyushu, Japan.

Journal of Dental Sciences

|October 3, 2025

Summary

Periodontal initial treatment improved brain function in patients with periodontitis. This dental intervention enhanced activity in key brain areas related to cognition, suggesting a link between oral health and cognitive restoration.

Keywords:

Brain activation Calculation task Language task Periodontal initial treatment fMRI

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Area of Science:

Neuroscience
Dentistry
Cognitive Science

Background:

A strong link exists between dental health and cognitive brain function.
Periodontal disease is associated with impaired cognitive functions, including working memory and selective attention.

Purpose of the Study:

To investigate the impact of periodontal initial treatment on brain functional activity.
To assess changes in brain activity following non-surgical periodontal therapy.

Main Methods:

16 patients diagnosed with periodontitis underwent periodontal initial treatment.
Treatment included oral hygiene instruction, scaling, and root planing.
Functional magnetic resonance imaging (fMRI) was used to measure brain activity before and after treatment.

Main Results:

Significant improvement in periodontal tissue health was observed post-treatment.
fMRI revealed increased brain activity in the dorsolateral prefrontal cortex and Wernicke's area during language and calculation tasks.
These cognitive tasks showed enhanced neural engagement after periodontal intervention.

Conclusions:

Periodontal disease negatively affects cognitive functions.
Periodontal initial treatment appears to aid in restoring brain function.
Findings highlight the potential of dental interventions to positively influence cognitive health.