Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cryo-deposited Au shells amplify nanozyme catalysis: A K<sub>m</sub>-enhanced immunoassay for mycotoxin screening.

Biosensors & bioelectronics·2026

Same author

CCL19<sup>+</sup> fibroblasts define a proliferative niche in chronic lymphocytic leukemia.

bioRxiv : the preprint server for biology·2026

Same author

Elevated soil temperature alters nitrogen uptake, allocation and utilization in maize during the late vegetative stage.

Plant physiology and biochemistry : PPB·2026

Same author

Poge heart-saving decoction meliorates heart failure by suppressing apoptosis and fibrosis via regulation of the PI3K/AKT pathway.

Frontiers in pharmacology·2026

Same author

NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype.

The American journal of surgical pathology·2026

Same author

Activity-specificity balanced Au@Pt nanozyme immunoassay via Dual-Au deposition for enhanced mycotoxin detection.

Current research in food science·2026

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

Optical Control of Leukotriene A4 Hydrolase Using Photoswitchable Inhibitors.

Xin Zhou¹, Shumei Wang¹, Xingye Yang^1,2

¹Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Journal of Medicinal Chemistry

|October 3, 2025

Summary

Researchers developed novel photoswitchable inhibitors targeting Leukotriene A4 hydrolase (LTA4H) for inflammatory diseases. Light-activated piLTA4H-1 effectively controlled LTA4H activity and inflammation in preclinical models.

More Related Videos

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Published on: March 28, 2016

Related Experiment Videos

Last Updated: Jan 16, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Published on: March 28, 2016

Area of Science:

Medicinal Chemistry
Pharmacology
Photochemistry

Background:

Leukotriene A4 hydrolase (LTA4H) is a key enzyme in inflammatory pathways, implicated in cardiovascular diseases, asthma, and cancer.
Precise optical modulation of LTA4H activity offers a novel therapeutic strategy for inflammatory conditions.

Purpose of the Study:

To design and synthesize novel azobenzene-based photoswitchable inhibitors of LTA4H.
To evaluate the efficacy of these inhibitors in modulating LTA4H activity and inflammatory responses in vitro and in vivo.

Main Methods:

Azobenzene moiety was incorporated to replace the diphenyl ether scaffold in the LTA4H inhibitor LYS006.
Ten azobenzene-based photoswitchable LTA4H inhibitors were synthesized and characterized for photochemical properties.
Enzymatic inhibitory assays, mouse whole blood assays, and a mouse model of arachidonic acid-induced ear dermatitis were employed.

Main Results:

piLTA4H-1 demonstrated a significant (approximately 150-fold) increase in LTA4H inhibition upon exposure to 365 nm light compared to dark conditions.
Photoswitchable piLTA4H-1 effectively modulated eicosanoid release in mouse whole blood.
piLTA4H-1 showed efficacy in intervening in arachidonic acid-induced ear dermatitis in mice.

Conclusions:

Azobenzene-based photoswitchable inhibitors represent a promising class of compounds for LTA4H targeted therapy.
Optical control of LTA4H activity using piLTA4H-1 offers a smart and effective strategy for inflammation intervention.
This approach holds potential for developing new treatments for inflammatory diseases both in vitro and in vivo.