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Decoding the regulatory role of noncoding RNAs in biological and vascular calcification

Jasmeen Kaur Lamba1, Simran Tandon2, Chanderdeep Tandon3

  • 1Amity University Punjab, Mohali, Punjab, 140308, India.

Molecular Biology Reports
|October 3, 2025
PubMed

Insights

Noncoding RNAs (ncRNAs) regulate vascular calcification (VC), a process similar to bone formation. Understanding ncRNA roles in VC offers insights into vascular and skeletal health.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Cardiovascular diseases, including vascular calcification (VC), are major global health issues.
  • VC involves pathological calcium deposition in arteries, resembling bone formation and involving endothelial-to-mesenchymal transition (EndMT).
  • Osteogenic markers in vascular tissue indicate a link between bone and vascular calcification.

Purpose of the Study:

  • To review the role of noncoding RNAs (ncRNAs) in regulating biological and vascular calcification.
  • To focus on the differential expression of ncRNAs and their impact on vascular and skeletal health.

Main Methods:

  • Review of current literature on ncRNAs and calcification.
  • Analysis of next-generation sequencing (NGS) data.
  • Focus on microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs).

Main Results:

  • ncRNAs play a critical role in regulating both biological and vascular calcification.
  • ncRNAs modulate key processes including transcription, translation, epigenetic modifications, oxidative stress, inflammation, and endothelial dysfunction.
  • Differential expression of ncRNAs is implicated in VC pathophysiology.

Conclusions:

  • ncRNAs are key regulators of vascular calcification.
  • Understanding ncRNA mechanisms provides potential therapeutic targets for VC.
  • ncRNA research offers insights into maintaining vascular and skeletal health.

Keywords:
AtherosclerosisBiological calcificationInflammationNoncoding RNAsOsteogenic markersVascular calcification

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