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Updated: Jun 20, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Intra-arterial bleomycin for treatment of labial arteriovenous malformations in children
Luis O Tierradentro-Garcia1, Mirindi Kabangu2, Juan G Tejada2,3
1Department of Radiology, Perelman School of Medicine, Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia, PA, USA.
Abstract:
Labial arteriovenous malformations (AVMs) pose a great challenge due to their location, angiogenic potential, and recurrence rate. Emerging treatments include sclerotherapy, such as intra-arterial bleomycin, which has been proven safe and effective in adults; however, there is limited literature available for children. Here, we present two successful cases of intra-arterial bleomycin use for treating lip AVMs in children, resulting in complete cure and no recurrence after a two-year follow-up period. Our findings support the limited but growing body of literature that presents intra-arterial bleomycin as a safe and viable option for pediatric facial AVMs.
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