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Supramolecular engineering of J-aggregated BODIPY derivatives with assembly-enhanced ROS generation for mitochondrial
Chun-Lin Yu1, Xue-Liang Liu2, Guo-Jiang Mao3
1Xinyang Central Hospital, Xinyang, Henan 464000, PR China.
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We engineered a mitochondria-targeting nanophotosensitizer (1a) through supramolecular J-aggregation of dual-pyridinium-functionalized twisted BODIPY derivatives. 1a overcomes aggregation-caused quenching (ACQ), while achieving assembly-enhanced ROS generation, demonstrating a 12.5× increase in singlet oxygen (1O₂) quantum yield versus its monomeric form. The cationic pyridinium moieties confer dual functionality: targeting mitochondria and enhancing aqueous dispersion. This design synergistically resolves key challenges in conventional PDT: precise spatiotemporal ROS generation and limited ROS yield in aggregated states, achieving 91 % tumor inhibition in murine tumor model.
