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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Normal Global Sagittal Alignment Radiographic Parameters in Patients Without Spinal Deformity.

Akiro H Duey1, Timothy Hoang1, Yash S Lahoti1

  • 1Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Global Spine Journal
|October 3, 2025
PubMed
Summary

This study establishes reference ranges for global sagittal alignment in individuals without spinal deformity. Age and sex significantly influence spinal alignment parameters, crucial for surgical planning.

Keywords:
EOSalignmentglobalsagittal

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Area of Science:

  • Orthopedics and Spine Surgery
  • Radiology and Imaging
  • Biomechanical Engineering

Background:

  • Global sagittal alignment is critical for spinal health and function.
  • Establishing normative data is essential for identifying spinal deformity.
  • Age and sex are known demographic factors that can influence spinal alignment.

Purpose of the Study:

  • To determine reference ranges for global sagittal alignment parameters.
  • To stratify these parameters by age and sex in a healthy cohort.
  • To provide a baseline for comparison in spinal deformity assessment.

Main Methods:

  • Retrospective cohort study of 518 patients without spinal deformity.
  • Biplanar full-body spine X-rays were analyzed.
  • Global sagittal alignment parameters were measured and stratified by age and sex.

Main Results:

  • Age was associated with increased cranial sagittal vertical axis to the sacrum (CrSVA-S) and hip (CrSVA-H) but decreased to the knee (CrSVA-K).
  • Male sex was associated with greater CrSVA-S, CrSVA-H, and ankle (CrSVA-A) compared to females.
  • No significant sex difference was found for CrSVA-K.

Conclusions:

  • This study provides normative reference values for global sagittal alignment.
  • Findings support operative planning and enhance understanding of spinal deformity.
  • Age and sex are significant determinants of normal sagittal alignment.