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Updated: Jan 16, 2026
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
First Post-Approval Clinical Use of F-18 Flurpiridaz With Exercise Cardiac PET in the United States
Suman Tandon1, Omar K Khalique2, Lu Q Chen1
1Division of Cardiovascular Imaging, St. Francis Hospital and Heart Center, Roslyn, New York, USA.
Background:
F-18 flurpiridaz is a novel radiotracer approved for positron emission tmography (PET) myocardial perfusion imaging. Its long half-life supports exercise stress testing, and its short positron range and high myocardial extraction fraction provide superior image resolution.
Early Reports Summary:
A 70-year-old man with known coronary artery disease and prior coronary revascularization underwent exercise cardiac PET with F-18 flurpiridaz for chest discomfort. PET showed ischemia in the left anterior descending and right coronary artery territories. Coronary angiography revealed a severe mid-left anterior descending lesion and a severe proximal lesion in a small-caliber right posterior descending artery.
Discussion:
Ischemia on PET correlated with coronary angiography and optical coherence tomography, guiding revascularization and altering clinical management.
Novelty:
This case represents the first post-approval clinical experience of F-18 flurpiridaz with exercise cardiac PET imaging in the United States.
Take-Home Message:
F-18 flurpiridaz has made exercise cardiac PET feasible in the clinical setting.
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