Related Experiment Video
Updated: Jan 16, 2026

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
Published on: December 1, 2023
Evaluation of post-laryngectomy dysphagia rehabilitation using High-Resolution impedance manometry: an exploratory
Marise Neijman1,2,3, Maarten J A van Alphen4,5, Rob J J H van Son4,6,5
1Department of Head and Neck Oncology and Surgery, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, the Netherlands. m.neijman@nki.nl.
Aim:
This exploratory study analyzes High-Resolution Impedance Manometry (HRIM) data obtained during a phase II rehabilitation trial in laryngectomees at baseline (T0), after six-weeks of resistance-based training (T1), and after eight weeks of rest (T2), exploring its potential value in alaryngeal dysphagia research and clinical practice.
Methods:
Pharyngeal HRIM was combined with videofluoroscopy to evaluate swallowing biomechanics in 17 laryngectomy patients. Parameters included Pharyngeal (Velo-, Meso-, and Hypopharyngeal) Contractile Integrals, Intra-Bolus Pressure, UES Relaxation Time, Maximum Admittance, and Integrated Relaxation Pressure.
Results:
No significant differences were found in the Pharyngeal Contractile Integrals, Intra-Bolus Pressure, Relaxation Time, Maximum Admittance, or Integrated Relaxation Pressure. However, pharyngeal pressures and Maximum Admittance slightly decreased from T0 to T1, and increased at T2 for all consistencies (thin, extremely thick, solid).
Conclusion:
Alaryngeal resistance-based swallowing exercises lead to small, non-significant differences in pharyngeal pressures. HRIM provides valuable insights, but its application for this population remains uncertain.
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