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Psychosis in Huntington's disease: A systematic review of case reports

Aliu Opeyemi Yakubu1, Oluwakemi Eunice Olalude2, Olorungbami Kolade Anifalaje3

  • 1General Adult Psychiatry, University Hospital Wishaw, Scotland, United Kingdom.

General Hospital Psychiatry
|October 4, 2025
PubMed

Insights

Psychosis in Huntington's disease (HD) often presents with delusions and hallucinations, typically before motor symptoms. Atypical antipsychotics and electroconvulsive therapy (ECT) show effectiveness in managing these debilitating symptoms.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Huntington's disease (HD) is a neurodegenerative disorder with diverse symptoms.
  • Psychosis is an uncommon yet severe psychiatric manifestation in HD patients.
  • This review focuses on characterizing psychosis in HD through case reports.

Conclusions:

  • Psychosis in HD presents across various ages and disease stages.
  • Atypical antipsychotics are generally effective; ECT is a safe adjunct for refractory psychosis.
  • Vigilance for psychosis as an early HD sign and multidisciplinary care are recommended.
Abstract

Keywords:
AntipsychoticsCase reportsDelusionsElectroconvulsive therapyHallucinationsHuntington's diseaseNeuropsychiatryPsychosis

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