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Published on: May 15, 2019
Laryngo-Onycho-Cutaneous Syndrome Managed With Thalidomide
Ellen Chinchilli1, Christopher J Yao1, Maria R Cordisco1
1Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.
None:
Laryngo-onycho-cutaneous syndrome (LOCS), a subtype of junctional epidermolysis bullosa, results from mutations affecting laminin-332 subunits which alter epidermal-dermal adhesion. LOCS phenotype includes cutaneous, ocular, and laryngeal granuloma formation and scarring. Management relies on multidisciplinary symptomatic care, and successful disease-modifying therapies are infrequently documented. Here, we describe a 7-year-old female with characteristic manifestations of LOCS who has had a significant response to oral thalidomide.
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