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Updated: Jan 16, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
When MOFs met SALI: solvent-assisted ligand incorporation in metal-organic frameworks for catalysis and beyond
Marzena Pander1, Emilian Stachura2, Magdalena Kozieł-Szymańska2
1Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland. marzena.pander@uj.edu.pl.
Abstract:
Solvent-assisted ligand incorporation (SALI) has emerged as a versatile and convenient post-synthetic modification (PSM) strategy for metal-organic frameworks (MOFs). By coordinating new ligands to unsaturated secondary building units (SBUs), SALI enables straightforward incorporation of a diverse range of organic ligands under mild conditions, avoiding the laborious synthesis often required in de novo approaches. Unlike many PSM methods relying on non-covalent or covalent modifications, SALI introduces functional ligands through direct dative bonds, making it broadly applicable in catalysis, gas separation, drug delivery, and beyond. This review provides a comprehensive overview of SALI advancements, highlighting its role in modifying MOFs and expanding their potential across various fields.
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