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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Imaging Studies VII: Vascular Imaging01:19

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

Updated: Jan 16, 2026

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
09:43

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

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Targeted Theranostic Strategy for Atherosclerotic Plaques Using Intravascular Multimodal Imaging Techniques.

Jin Hyuk Kim1,2, Hongki Yoo3, Kyeongsoon Park4

  • 1BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea.

Journal of Lipid and Atherosclerosis
|October 6, 2025
PubMed
Summary

New theranostic strategies precisely target and resolve inflamed atherosclerotic plaques using advanced imaging. This approach offers personalized, imaging-guided therapies for cardiovascular disease, improving patient outcomes.

Keywords:
AtherosclerosisInflammationMacrophageMultimodal imagingPrecision medicine

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Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Atherosclerosis is a chronic inflammatory disease causing plaque rupture, leading to myocardial infarction and stroke.
  • Current therapies struggle to target inflamed plaques, causing off-target damage and complications like thrombosis.
  • Existing theranostic strategies show limited efficacy in human coronary arteries.

Purpose of the Study:

  • To develop advanced theranostic strategies for precise targeting and resolution of high-risk atherosclerotic plaques.
  • To overcome limitations of current therapies and theranostic approaches in human cardiovascular disease.
  • To enable personalized, imaging-guided treatment for atherosclerosis.

Main Methods:

  • Utilizing multimodal imaging techniques, including optical coherence tomography (OCT) and near-infrared fluorescence (NIRF).
  • Implementing targeted drug delivery and photoactivation strategies for plaque inflammation.
  • Combining structural and molecular imaging for real-time visualization and treatment.

Main Results:

  • OCT provides high-resolution structural imaging, while NIRF detects inflammatory activity.
  • Theranostic strategies accurately localize and target macrophage- and lipid-rich plaques.
  • Targeted delivery and uptake by plaque macrophages enable rapid inflammation resolution and plaque stabilization.

Conclusions:

  • Clinically relevant theranostic strategies offer a promising path for personalized, imaging-guided cardiovascular disease therapies.
  • These advancements could revolutionize the diagnosis and treatment of atherosclerosis.
  • The developed strategies demonstrate potential for improving outcomes in human coronary artery disease.