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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Ischemic stroke and intervention strategies based on the timeline of stroke progression: Review and prospects
Anning Xu1, Honghua Zhang1, Yihua Zhang1
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.
Insights
Novel therapeutic strategies are needed for ischemic stroke (IS) due to limited treatment windows. This review analyzes IS progression stages and interventions, highlighting future research directions for better outcomes.
Area of Science:
- Neurology
- Vascular Biology
- Pathophysiology
Background:
- Ischemic stroke (IS) is a major global health concern, often caused by cerebral vessel occlusion.
- Current treatments like thrombolysis and thrombectomy have narrow therapeutic windows, necessitating new approaches.
- Understanding IS progression is key to developing effective interventions.
Purpose of the Study:
- To analyze the four pathophysiological stages of ischemic stroke (IS).
- To evaluate established and emerging therapeutic strategies and their molecular mechanisms.
- To identify challenges and future research directions in IS therapy.
Main Methods:
- Comprehensive literature review of IS pathophysiology.
- Analysis of intervention targets across different IS stages.
- Evaluation of therapeutic strategies, including molecular mechanisms.
Main Results:
- Detailed examination of four distinct IS progression stages.
- Assessment of current and novel therapeutic options for IS.
- Identification of molecular mechanisms underlying IS treatments.
Conclusions:
- Timely, stage-specific therapeutic approaches are crucial for optimizing IS treatment outcomes.
- Further research into novel strategies and innovations is essential for advancing IS care.
- A deeper understanding of IS pathophysiology can guide the development of more effective interventions.
Abstract:
Ischemic stroke (IS), a leading cause of morbidity and mortality worldwide, primarily results from blood clot formation in cerebral vessels, leading to vessel occlusion, reduced cerebral blood flow, and subsequent tissue ischemia. While thrombolytic therapies and mechanical thrombectomy remain cornerstone treatments for restoring blood flow, their clinical efficacy is significantly limited by the narrow therapeutic window, which underscores the critical need for novel, safe, and effective therapeutic strategies. In this review, we present an intensive analysis of four pathophysiological stages of IS progression and their intervention targets, and evaluate both established and emerging therapeutic strategies with the molecular mechanisms underpinning these methods, aiming to enhance the understanding of IS intervention. Additionally, we discuss current challenges in IS therapy, emphasizing the importance of timely, stage-specific approaches to optimize therapeutic outcomes. Finally, we highlight some promising research directions and innovations to advance IS field.
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