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Published on: September 20, 2018
ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP) CAUSED BY ANTIBIOTIC POLYTHERAPY: A CASE REPORT
Siniša Jolić1, Zdenka Šitum Čeprnja2, Toni Čeprnja3
1Department of Dermatology and Venereology, Kikinda General Hospital, Kikinda, Serbia.
Abstract:
Acute generalized exanthematous pustulosis (AGEP) is a rare disease, usually associated with drug intake or infections. It is characterized by generalized acute pustules and non-follicular exanthema together with systemic symptoms. Histologically, it is characterized by a subcorneal intraepidermal spongiform pustule, papillary edema and dermal vasodilatation surrounded by a polymorphous infiltrate of neutrophils, eosinophils and mononuclear cells. The aim of this article is to present current knowledge regarding the etiology and treatment, as well as the clinical and histologic features of AGEP. We present a case of a 50-year-old male patient who was prescribed several antibiotics and developed a drug-related cutaneous adverse effect. Treatment involved rapid identification of the causative agent and its discontinuation together with supportive measures, with resolution of symptoms within two weeks. Early diagnosis and timely treatment result in a favorable outcome and prevent systemic complications.
Insights
Acute generalized exanthematous pustulosis (AGEP) is a rare, drug-induced skin condition. Promptly stopping the offending agent and providing supportive care leads to symptom resolution and prevents complications.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse drug reaction.
- It presents with generalized pustules, exanthema, and systemic symptoms.
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