Related Experiment Video
Updated: Jan 16, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
CORRELATION OF TPO ANTIBODY CONCENTRATION WITH THYROID HORMONES AS A PREDICTOR OF CLINICAL HYPOTHYROIDISM
Mila Vasilj-Mihaljević1,2, Ivan Mihaljević3,4,5, Sanja Bekić2,6
1Health Center Vukovar, Vukovar, Croatia.
Abstract:
This study aimed to determine the relationship between the concentration of thyroid peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study included 144 patients diagnosed with chronic lymphocytic thyroiditis whose mean age was 46±15 years at the time of diagnosis. According to their TSH concentration, the patients were either euthyroid or hypothyroid. After 59 patients were excluded due to TSH levels below the reference range, no TPO-Ab findings, substitution therapy, immune hyperthyroidism, or TPO-Ab and TSH levels outside the reso- lution limits of the laboratory tests, 85 patients remained in the study. A positive correlation was found between TPO-Ab and TSH concentration within the euthyroid and hypothyroid range and a negative correlation between TPO-Ab and FT4 concentration. The result suggests that the TSH and TPO-Ab concentration could be used to identify individuals at risk for the development of hypothyroidism in the general population.
More Related Videos
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Receiver Operating Characteristic Plot
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Therapeutic Drug Monitoring: Affecting Factors