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Updated: Jan 15, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Divergent Synthesis of Eudesmane Sesquiterpenoids
Ashutosh Panigrahi1, Kiran Kumar Pulukuri1
1Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517619, India.
None:
Demonstrated herein is a streamlined, unified strategy for the asymmetric, protecting-group-free synthesis of seven oxidized eudesmane congeners. A hydroxy-functionalized decalin scaffold bearing two orthogonally reactive olefins is constructed via an enantioselective tandem Michael addition-Aldol sequence, followed by a stereoselective Au(I)-catalyzed Alder-ene cyclization to establish the eudesmane core. Subsequent strategic late-stage hydrogenation and epoxidation enabled short and scalable access to structurally diverse eudesmane congeners, underscoring the platform's broad potential for complex terpenoid synthesis.
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