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Three new compounds from the roots of Rubia cordifolia
Wan-Qi Zhang1, Xin-Yue Li1, Ming-Hui Sun1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
Three new compounds (1-3), including two cyclopentanoid monoterpenes rubicoside A (1) and rubicocin A (2), and one naphthohydroquinone glycoside rubinaphthin E (3), together with six known analogues (4-9), were isolated from the roots of Rubia cordifolia. The structures of compounds 1-3 were established by chemical methods and spectroscopic analysis. Compounds 1-9 were tested for their cytotoxicity and screened for stable transfection of recombinant dopamine receptors in HEK293 cell lines.
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