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Updated: Jan 15, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
[Use of modern imaging in dermatosurgery]
Lukas Kofler1,2, Katrin Kofler3,4, Maximilian Deußing5,6
1Hautzentrum am Holzmarkt, Holzmarkt 6, 88400, Biberach a.d.R., Deutschland. l.kofler@hautzentrum-holzmarkt.de.
None:
Dermatosurgery plays a pivotal role in the management of cutaneous neoplasms, aiming not only at complete tumor removal but also at preserving functional and esthetic integrity. While conventional histopathology ensures high diagnostic accuracy, it is limited by processing time, artifacts, and restricted intraoperative availability. Novel imaging techniques such as confocal laser microscopy (CLM), optical coherence tomography (OCT), and line-field confocal OCT (LC-OCT) provide new opportunities for preoperative mapping, intraoperative margin assessment, and postoperative surveillance. Ex vivo confocal microscopy further allows rapid tissue analysis with minimal specimen loss. The synergistic use of multiple imaging modalities, together with artificial intelligence-assisted image interpretation, holds significant potential to refine dermatosurgical practice. These advances may contribute to more precise, patient-centered surgical care and reduce unnecessary re-operations.
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