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Updated: Jan 15, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines
Gabriel Pereira da Costa1, Bruna Rafaella Schneider2, Angelita Manke Barcellos2
1Núcleo de Estudo Estrutural e Síntese de Heterociclos - NEESH, Universidade Federal do Rio Grande - FURG, Escola de Química e Alimentos - EQA, Itália Ave., km 8, Campus Carreiros, Rio Grande, 96.203-900, RS, Brazil.
Abstract:
This review article highlights the significant advances in the synthesis of dibenzo[b,f]oxepines over the past decade. Dibenzo[b,f]oxepines, important heterocyclic compounds, have attracted increasing interest due to their wide-ranging applications in medicinal chemistry and materials applications. The review addresses traditional approaches and recent developments, highlighting efficient synthetic strategies such as cross-coupling reactions, intramolecular cyclizations, and molecular diversification strategies. Additionally, the efficiency, selectivity, and sustainability of these methods are discussed. Emerging trends and future challenges in the synthesis of dibenzo[b,f]oxepines are also explored, including the search for more sustainable methods, the expansion of structural diversity, and the optimizing reaction conditions. This review provides a comprehensive overview of recent advances in this field, providing valuable insights for researchers aiming to develop novel synthetic strategies and applications for dibenzo[b,f]oxepines.
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