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Serum Metallome Features and Their Effects on Chronic Kidney Disease: A Comparative Study
Jiuyi Jiang1,2, Lingxiao Hu1,3, Chunmei Dai1,2
1Department of Medical Laboratory, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
International Journal of General Medicine
|October 7, 2025
Summary
Chronic kidney disease (CKD) patients show altered metal levels, with specific metals like aluminum (Al), vanadium (V), and lead (Pb) predicting CKD onset. Monitoring these metals may help in early detection and assessing disease progression.
Area of Science:
- Environmental Health
- Nephrology
- Toxicology
Background:
- Epidemiological studies indicate a link between metal exposure and kidney dysfunction.
- Chronic kidney disease (CKD) is a growing public health concern with complex etiologies.
- Understanding the role of metals in CKD pathogenesis is crucial for prevention and treatment.
Purpose of the Study:
- To investigate metallome profiles in CKD patients.
- To determine the relationship between metal concentrations and kidney function markers.
- To identify metals associated with CKD onset and progression.
Main Methods:
- A cohort study involving 341 CKD patients and 60 healthy controls.
- Assessment of serum levels for 26 metal elements.
- Analysis of renal function markers including urea, creatinine, uric acid, cystatin C, and C1q.
- Logistic regression models to identify predictors of CKD onset and progression.
Main Results:
- CKD patients exhibited significantly different serum concentrations for 18 metals compared to healthy controls.
- Serum levels of aluminum (Al), vanadium (V), cobalt (Co), gallium (Ga), cesium (Cs), and lead (Pb) were identified as independent predictors of CKD onset.
- Metals such as lithium (Li), V, molybdenum (Mo), and Cs were associated with CKD progression.
- Significant correlations were found between several metal pairs, including positive correlations between Al and V, Al and Ga, and V and Ga.
Conclusions:
- CKD patients display distinct serum metallome profiles.
- Specific metals (Al, V, Co, Ga, Cs, Pb) are implicated in CKD onset, while others (Li, V, Mo, Cs) are linked to its progression.
- Monitoring serum levels of metals like V, Pb, and Mo may assist in early CKD detection and progression assessment.
Keywords:
chronic kidney diseasemetabolic profilesmetallomeultra-high performance liquid chromatography-tandem mass spectrometryMore Related Videos
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