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COPD and the burden of multimorbidity: navigating the complexity
Maria Kallieri1, Georgios Hillas1, Konstantinos Bartziokas1
12nd Respiratory Medicine Department, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Expert Review of Respiratory Medicine
|October 7, 2025
Summary
Managing chronic obstructive pulmonary disease (COPD) with multimorbidity requires a multidisciplinary approach. This strategy combines treatments for COPD and its comorbidities, addressing shared risk factors for better patient outcomes.
Area of Science:
- Pulmonary Medicine
- Internal Medicine
- Geriatrics
Background:
- Chronic obstructive pulmonary disease (COPD) is a prevalent global health issue.
- Most COPD patients exhibit multimorbidity, with coexisting conditions like cardiovascular disease, osteoporosis, lung cancer, and metabolic syndrome.
- The presence of multiple diseases complicates COPD diagnosis, treatment, and prognosis.
Purpose of the Study:
- To explore the mechanisms linking COPD and multimorbidity.
- To highlight challenges in managing multimorbid COPD patients.
- To emphasize the need for a multidisciplinary approach in COPD care.
Main Methods:
- Literature review of shared risk factors and pathophysiological pathways.
- Analysis of management strategies for multimorbid COPD patients.
- Synthesis of evidence-based guidelines for COPD and comorbidity management.
Main Results:
- Identified shared risk factors and pathophysiological links between COPD and other chronic diseases.
- Highlighted complexities in diagnosing and treating COPD patients with multiple comorbidities.
- Emphasized that managing multimorbidity in COPD necessitates a comprehensive, multidisciplinary strategy.
Conclusions:
- A multidisciplinary approach is essential for managing COPD patients with multimorbidity.
- Integrated care plans should combine COPD treatments, comorbidity management, and risk factor modification.
- This comprehensive strategy aims to improve overall patient outcomes in complex cases.
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