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Published on: November 4, 2010
Corneal Sealants in Pre-Clinical Development
Jackie Tan1, Leslie John Ray Foster1,2, Frank James Lovicu1
1Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Save Sight Institute, Sydney, Australia.
Purpose:
To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.
Method:
A systematic review of major databases from inception to 4th March 2025.
Results:
Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.
Conclusion:
A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.
