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Corneal Sealants in Pre-Clinical Development.
Jackie Tan1, Leslie John Ray Foster1,2, Frank James Lovicu1
1Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Save Sight Institute, Sydney, Australia.
Current Eye Research
|October 7, 2025
Summary
This review examines pre-clinical corneal sealants and adhesives, identifying biological and synthetic options. Future developments should prioritize biocompatibility and effective wound sealing for improved patient outcomes.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Corneal wounds pose significant risks, necessitating effective sealing solutions.
- Current treatments often have limitations in efficacy and healing promotion.
Purpose of the Study:
- To systematically review pre-clinical corneal sealants and adhesives.
- To guide future development of these critical ophthalmic materials.
Main Methods:
- A comprehensive systematic review of major scientific databases.
- Inclusion of studies from inception up to March 4, 2025.
Main Results:
- Corneal sealants and adhesives are categorized as biological or synthetic, with various adhesion activation methods.
- Identified materials include fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, and natural polymers like collagen and hyaluronic acid.
- Burst pressure is a key metric for sealing efficacy; ideal characteristics include biocompatibility, high burst tolerance, on-demand activation, accelerated healing, and infection prevention.
Conclusions:
- Numerous corneal sealants and adhesives are under development for wound closure.
- Effective sealants and adhesives must possess specific properties to prevent leakage and promote healing.
